Here's what you can expect if you are submitting your manuscript to publishers for consideration:
Expect a wait! Most publishers list their response time in their submission guidelines, which can be up to six months or more. In addition, many of the larger publishers receive hundreds of unsolicited manuscripts each week, and it takes time to go through this slush pile.
Don't expect a response. It's not good business, but many times publishers fail to respond to the rejections. If it's past their normal response time, send an email query. After that, just move on...
Expect disappointment. Again, publishers receive many, many submissions. You WILL receive some rejection letters. Get over it and keep moving.
Don't expect success if you are sending your manuscript one publisher at a time. Send your queries out in batches every single month. Yes, even if they say they want to be the only one reviewing your work! At that rate, you might be dead by the time you receive a positive response.
Expect to hire a lawyer schooled in publishing or entertainment law if you receive a contract. NEVER, EVER sign a contract otherwise!
Don't expect to make a lot of money, especially if you are a first-time author. They will offer you a small percentage of the net profits and keep as many rights as possible. Yes, this is normal!
If you approach submitting your manuscript with the right expectations, you will not be so discouraged with the results! Keep after it until you find success!